An agenda for operations research. Abstract. Operations research (OR) is well established in India and is also a prominent feature of the global and local agendas for tuberculosis (TB) control. India accounts for a quarter of the global burden of TB and of new cases. Multidrug- resistant TB is a significant problem in Mumbai, India’s most populous city, and there have been recent reports of totally resistant TB. Much thought has been given to the role of OR in addressing programmatic challenges, by both international partnerships and India’s Revised National TB Control Programme. We attempt to summarize the major challenges to TB control in Mumbai, with an emphasis on drug resistance. Specific challenges include diagnosis of TB and defining cure, detecting drug resistant TB, multiple sources of health care in the private, public and informal sectors, co- infection with human immunodeficiency virus (HIV) and a concurrent epidemic of non- communicable diseases, suboptimal prescribing practices, and infection control. We propose a local agenda for OR: modeling the effects of newer technologies, active case detection, and changes in timing of activities, and mapping hotspots and contact networks; modeling the effects of drug control, changing the balance of ambulatory and inpatient care, and adverse drug reactions; modeling the effects of integration of TB and HIV diagnosis and management, and preventive drug therapy; and modeling the effects of initiatives to improve infection control. Keywords. Tuberculosis; Public health; Global health. Introduction. Operations research, India, and tuberculosis. India has operations research (OR) history. Established in 1. International Federation of Operational Research Societies (IFORS), the Operational Research Society of India was the first in the South, and hosted the first international conference on OR for Development, in Ahmedabad in 1. ORSI: www. orsi. in). Nevertheless, OR on public health has been limited, and in this India is no exception . In a recent discussion, Royston suggests that OR has a rather broader interpretation in global health than in management science . Health initiatives have tended to use group methods of qualitative character (brainstorming, behavioral simulation, scenario analysis, system mapping), rather than quantitative exercises such as mathematical modeling and system dynamics. We think this is true, but understandable. Proponents of OR for global health–and for TB control in particular–see it as research “intended to provide managers, administrators, and policy makers with the information that they need to improve service delivery activities and plan future ones” . This sort of language is less intimidating than “an interdisciplinary branch of applied mathematics or formal science that uses advanced analytic methods to make better decisions or research that provides optimal solutions to complex decision- making” (http: //www. It turns out that OR for health in low- income countries has been championed by people involved in tuberculosis (TB) control, from making the case for OR . The sort of OR that might be described as implementation science is crucial to the success of TB programmes . Substantial efforts have been made to support OR for TB control through funding, training and guidelines, but it is not always clear that it has delivered . Commentaries call for greater coordination — for activity to be more programme- driven than researcher- driven — . The sixth concern is the need for research, and the Global Plan to Stop TB 2. OR (http: //www. stoptb. TB causes an estimated 3. India: 1. 7. 6% of communicable disease deaths and 3. While the incidence has fallen from 2. India contributed 2. TB globally, but 4. The primary notional provider of care is the Revised National TB Control Programme (RNTCP): Fig. Fig. Schematic overview of key tuberculosis control activities in India’s Revised National Tuberculosis Control Programme. Mumbai. If one wanted to design an environment conducive to the spread of TB, failure of treatment, and emergence of resistance, Mumbai would fit the remit. A land- starved megacity in which a resident population of 1. The city has a mean population density of 4. TB is a disease of poverty and marginality . Coupled with this are epidemics of non- communicable disease: 3. Tobacco and alcohol use are common, and diabetes — which affects an estimated 4. The UVRI-IAVI HIV Vaccine Program (the Program), founded in 2001, is a not for profit organization with offices and research facilities based at the Uganda Virus Research Institute in Entebbe. The Program’s main activities. International postgraduate centre devoted to research, education and training and consultancy. Includes history of the school, news and events. The TB South Africa project has a large grants program, supporting organizations all over South Africa doing a variety of TB work. For grant information, please click here to send e-mail to Hyla van den Berg. Framework for Program Evaluation in Public Health. Health improvement is what public health professionals strive to achieve. To reach this goal, we must devote our skill -- and our will -- to evaluating. The home page for SPEC, the Standards Performance Evaluation Corporation, a standards body for performance benchmarks. Lab: Als Laboratory Department: Psychiatry Division Psychology Research Hospital Title: Director, Neurobehavioral Infant and Child Studies Academic Title: Professor of Psychology, Harvard Medical School Research Focus Area. Over 9 million CITI Program courses have been completed since 2000. 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